CrystalBreeder

CrystalBreeder is the next generation multi-reactor crystallization platform for medium-throughput solid-state research, operating at working volumes of 0.1 mL. Run rapid complete crystallization screens with as little as 1 mg of sample. CrystalBreeder provides real time turbidity readings for 32 parallel temperature controlled experiments. When early solubility information is essential, stop guessing and let CrystalBreeder put you in the lead.

To decrease the time to market, effective innovation is vital. Early-stage solid-state screening is necessary to avoid costly developmental surprises later. Similarly, there is a requirement for salt screening early on in the development process, since changing salt form at a later stage may cause costly delays to the entire process.

Investigate small amounts of sample under controlled conditions, with CrystalBreeder: simply and reliably. Complete a salt screen with as little as 1 mg of compound at working volumes of 0.06 – 0.1 mL. Top stirring is now available with CrystalBreeder and was specifically developed to overcome attrition issues.

Reaction conditions are more reproducible and realistic than in well-plate experiments, whilst in vial analytics measure turbidity in each reactor without physical contact with the sample. Real-time display of turbidity provides an immediate and reliable signal when a sample crystallizes.

Technobis Crystallization Systems is a world leading technology provider for solid-state research, process development and formulation. Our mission is to help research succeed!

Since 2005, platforms for accelerating crystallization research have been successfully developed and installed in nearly every pharmaceutical research lab in the world. With more than 600 units in the field, a large community of scientists have been enabled to make a significant contribution to the accelerated development of new pharmaceuticals. In the last few years, new applications have been developed in agrochemical, fine chemical, military and (bio) fuel research, food and personal care creating new markets focused on understanding the importance of crystallization research.

Our workflow consists:

The CrystalBreeder™ is the first crystallizer dedicated for both development and discovery, carrying out complete crystallization screens with as little as 1mg of sample.

The Crystal16® parallel crystallizer is a multiple reactor station providing a screening solution for solubility determination, solid-state research and process development: medium-throughput crystallization studies at a 1ml scale.

With 8 independently controlled reactors and additional analytical capabilities, the Crystalline™ is a unique modular product line at a working volume of 5 ml for solid-state research, process development and formulation research.

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