Crystalline


Every picture tells your story 

A new analytical instrument that allows scientists to access crystallization and formulation information at milliliter scale.

Every picture tells your story

The Crystalline PV/RR combines temperature and turbidity measurements with real time particle imaging. With eight in-line high quality digital visualization probes reaching 0.63 microns per pixel, seeing what is happening in the vial has never been easier: no moving parts, no cumbersome insertion probes. With a robust design, the probes are contained in a sealed, pre-aligned and sturdy environment, giving the user walk-up access to eight parallel particle view cameras.

You can now visualize the complete crystallization or formulation processes, and access real time particle size and shape information at the smallest scale.

See what’s happening

Have you ever wondered what is happening during the crystallization or formulation processes? How do you know if the sample is aggregating, foaming or oiling out?

Take the guesswork out of crystallization studies with the Crystallline PV/RR. You can easily correlate the turbidity signals with visual information finally getting the complete picture of the crystallization or formulation processes.

  • Polymorph and solvate screening
  • Monitoring of habit changes
  • Searching for less stable intermediates
  • Controlling growth of certain polymorphs
  • Develop and optimize your process
  • Optimize and control your formulation process

The instrument comes with eight cameras positioned in a standard configuration, capable of up to 6.0 times magnification.

The resolution of 0.63 microns per pixel can be reached without any problems, making information close to nano scale easily available while you are performing your experiments.

Technobis Crystallization Systems is a world leading technology provider for solid-state research, process development and formulation. Our mission is to help research succeed!

Since 2005, platforms for accelerating crystallization research have been successfully developed and installed in nearly every pharmaceutical research lab in the world. With more than 600 units in the field, a large community of scientists have been enabled to make a significant contribution to the accelerated development of new pharmaceuticals. In the last few years, new applications have been developed in agrochemical, fine chemical, military and (bio) fuel research, food and personal care creating new markets focused on understanding the importance of crystallization research.

Our workflow consists:

The CrystalBreeder™ is the first crystallizer dedicated for both development and discovery, carrying out complete crystallization screens with as little as 1mg of sample.

The Crystal16® parallel crystallizer is a multiple reactor station providing a screening solution for solubility determination, solid-state research and process development: medium-throughput crystallization studies at a 1ml scale.

With 8 independently controlled reactors and additional analytical capabilities, the Crystalline™ is a unique modular product line at a working volume of 5 ml for solid-state research, process development and formulation research.

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